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Researchers have proposed several mechanisms, including direct effects on gene transcription factors and indirect influences through cellular signaling cascades that regulate telomerase activity

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FIGURE 1 Modulation of antioxidant levels in GK rat liver and kidney after exercise The level of GSH, an endogenous antioxidant synthesized abundantly in the liver was significantly reduced in both the liver and kidney (50%–60%) of GK diabetic rats (Figure 2A)